Cartilage transplant techniques explained

Written by: Mr James Donaldson
Published: | Updated: 11/04/2023
Edited by: Top Doctors®

Osteoarthritis affects a quarter of people over 50. It results from the gradual wearing down of the cartilage between joints. Cartilage is incredibly hard-wearing but can be injured in younger patients which prematurely begins the arthritis process. Unfortunately, cartilage does not regrow or regenerate. Thankfully, orthopaedic surgeons can now carry out cartilage transplants in appropriate patients.

The two-stage procedure

Over the last fifteen years, a technique of two-stage cartilage transplant has been developed. It heals the joint, relieves pain and restores function. It has a high success rate and delays the onset of osteoarthritis, preventing the need for a joint replacement. Firstly, the knee is examined telescopically. A small piece of cartilage is removed and sent to a laboratory where it is cultured for four to six weeks to increase the number of cartilage cells. The cells are then transplanted back into the damaged area of the knee where a new cartilage surface is created. The method is successful in relieving pain and restoring activity in younger patients. However it requires two operations, it is costly and the rehabilitation period before full activity is long, taking up to 12 months.

Using stem cells

More recently a novel, single-stage procedure has been developed for treating osteoarthritis using the patient’s own stem cells. The cells are taken from the patient’s bone marrow in the pelvis using a small needle and centrifuged in a special machine in the operating room. This provides a concentrated amount of stem cells, which are transplanted into the knee joint, creating new cartilage cells to repair the damaged part of the joint. Only one operation and hospital stay are required using this method, rehabilitation is accelerated and the procedure is more cost effective. This technique will also hopefully provide future possibilities for the treatment of other joints such as the hip, ankle and the upper limbs.

By Mr James Donaldson
Orthopaedic surgery

Mr James Donaldson is one of London's most highly-skilled orthopaedic surgeons. Operating from the Royal National Orthopaedic Hospital, he has a special interest in hip replacements, knee replacements, using stem cells for cartilage replacements, soft tissue knee surgery, arthroscopic knee surgery and ligament reconstruction. He is also the clinical director of the joint reconstruction unit at the Royal National Orthopaedic Hospital.

Mr Donaldson was awarded his first medical qualification at University College London Medical School in 2002, receiving a certificate of merit in his MB finals. He then worked on the Royal National Orthopeadic Hospital rotation until 2013 to complete his training. Mr Donaldson went on to complete two sub-specialist fellowships: a one-year international fellowship in Toronto, Canada and a six month fellowship at Stanmore on the joint reconstruction unit. He is currently a consultant orthopaedic surgeon at the Royal National Orthopeadic Hospital. He additionally worked as consultant at the Royal Free Hospital in Hampstead. He is on the clinical governance committee at Stanmore and also sits on a number of multidisciplinary national meetings for complex case referral. 

Throughout Mr Donaldson's illustrious career, he has been awarded ten academic prizes including a surgery distinction in 2000 and a pharmacology certificate of merit in 1998. Later on his career, he was awarded the Royal College of Surgeons Preiskel Elective Prize in 2001 and the Jacques Duparc prize from the European Federation of National Associations of Orthopaedics and Traumatology in 2009. He has written numerous textbook chapters and articles in peer-reviewed journals and has co-authored a website for junior orthopaedic trainees and medical students. He is a member of a number of professional bodies such as the British Orthopaedic Association and the Royal College of Surgeons.

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