What is electrochemotherapy?

Written by: Mr Alastair MacKenzie Ross
Published: | Updated: 02/05/2023
Edited by: Conor Dunworth

 Electrochemotherapy is a method to treat cancer using a special probe to send electrical pulses into the cancer cells. The cancer cells are targeted allowing lower doses of chemotherapy to be used, which enters the cells more easily. It has lower risks of side effects than chemotherapy alone. The National Institute for Health and Care Excellence (NICE) has approved its use.  


Types of cancer that electrochemotherapy is used for

Electrochemotherapy can be used for cancers that can be accessed by the electrodes, which are commonly cancers found in or under the skin. The skin cancers basal cell carcinoma and squamous cell carcinoma, that has not spread, can be treated with the intent to cure them.

Other cancers that can be treated by electrochemotherapy that have spread to or under the skin are:

  • Breast cancer
  • Pancreatic cancer
  • Melanoma
  • Angiosarcoma - cancer of the inner lining of blood vessels in any area of the body
  • Karposi sarcoma - cancer caused by a virus, which first appear as spots or lesions on the skin


Electrochemotherapy treatment process

A patient will have the chemotherapy (either cisplatin or bleomycin) as either an injection into the tumour or an injection into the bloodstream through a small tube. The dose is lower than with standard chemotherapy treatment as the electric pulse helps the chemotherapy enter through the cell wall. The treatment can take between 10 to 60 minutes depending on how many tumours a patient has.


Side effects of electrochemotherapy

Side effects can include pain where the electrode touches the skin, visible marks from the electrode pins and the treatment not being fully effective. There can be risks of the chemotherapy drug, depending on which one is used. It can require a general anaesthetic.


Why should patients opt for electrochemotherapy over other procedures?

Electrochemotherapy is one of a number of treatments for cancer. As a newer treatment, the evidence supporting its effectiveness is not as established as other treatments. A decision to use it needs to be carefully weighed with other treatments by the doctor and his team of experts. Its advantages mean that the side effects are generally fewer and less significant than other treatments, for example the scarring of an operation to remove a cancer and the long term risks of other cancers from radiotherapy.

By Mr Alastair MacKenzie Ross
Plastic surgery

Mr Alastair MacKenzie Ross is one of London's leading consultant plastic surgeons. He specialises in skin cancer (including melanoma), electrochemotherapy, reconstruction and scars.

Mr Mackenzie Ross qualified in medicine from the University of Cambridge in 1996 and went on to complete his higher surgical training in London. He undertook a hand surgery fellowship in Singapore in 2010 and the following year returned to London to complete a cosmetic reconstructive surgery interface fellowship. In 2012, he was awarded a further prestigious fellowship in melanoma and surgical oncology at the Melanoma Institute Australia. He is a core member of the multi-disciplinary teams for melanoma and non-melanoma cancer at Guy's and St Thomas' Hospitals, and a founding member of the multi-disciplinary skin cancer team at the Wellington Hospital. Additional to his work within the NHS, Mr MacKenzie Ross sees private patients at the OneWelbeck clinic.

Mr Mackenzie Ross’ many years of clinical experience along with his strong academic background make him a leading expert in the field of plastic surgery. He was formerly the surgical lead for the London Cancer Alliance Skin Cancer Pathway Group and has teaching and training responsibilities in his role of clinical supervisor within Guy’s and St Thomas’ Hospitals. His academic work is widely published in peer-reviewed journals.

In keeping with best practice, skin cancer patients under Mr MacKenzie Ross’ care are managed with the benefit of input from the whole multi-disciplinary team. Electrochemotherapy is at the cutting-edge of cancer management and Mr MacKenzie Ross is one of the first to offer this treatment privately in London.

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