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All about cooled radiofrequency denervation for chronic knee pain

Top Doctors
Written in association with: Top Doctors editorial
Published: 09/07/2025 Edited by: Conor Lynch on 09/07/2025

Cooled radiofrequency denervation (CRFD) is an emerging, minimally invasive procedure used to treat chronic knee pain, particularly in patients with osteoarthritis or persistent pain after knee replacement surgery. This technique targets the genicular nerves, which are responsible for transmitting pain signals from the knee to the brain.


Unlike traditional radiofrequency ablation, CRFD uses a cooled probe to deliver controlled heat to the nerve tissue. The cooling process allows the energy to create a larger lesion around the nerve, increasing the chances of effective pain relief while reducing damage to surrounding tissues. The procedure is typically performed on an outpatient basis under local anesthesia, and it takes less than an hour.


Patients suitable for CRFD often have not responded adequately to conservative treatments such as physical therapy, medications, or corticosteroid injections. Before undergoing the procedure, most patients receive a diagnostic nerve block to confirm that the targeted nerves are the source of the pain. If the block provides temporary relief, the patient may be a good candidate for CRFD.


Studies have shown that CRFD can significantly reduce knee pain and improve function for up to 12 months or more, depending on individual factors. The benefits include reduced need for opioid painkillers, quicker return to daily activities, and minimal recovery time. Side effects are typically mild and may include temporary soreness at the treatment site.


While CRFD is not a permanent cure, it offers a valuable option for managing chronic knee pain, especially in patients who are not ready for or cannot undergo surgery. As research continues to advance, CRFD is becoming an increasingly popular tool in the multidisciplinary approach to knee pain management, offering hope to patients seeking long-lasting relief without major intervention.

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