Polynucleotides: a comprehensive guide

Polynucleotides are injectable elastic and reabsorbable gel-like products, used to reduce wrinkles, diminish crepiness, scars, and brown spots, tighten pores, and reduce stretch marks on the body. Renowned dermatologist Dr Ariel Haus explains more about the treatment, including how they differ from similar treatments and how long it takes to see the results.

What are polynucleotides?

Polynucleotides in the simplest of terms are injectable, sterile and highly purified products, derived from fish, typically salmon or trout.  The polynucleotides are then incorporated into a polymerised injectable gel, which once injected binds with water molecules to make skin tissue firmer and more hydrated. 

Some people refer to them as “biostimulators” because the polynucleotide chain has an anti-free radical action and serves as a scavenger of hydroxyl radicals, which accumulate due to stress and UV radiation (sun damage). The hydration and anti-free radical properties of polynucleotides help to create the optimal environment for fibroblast growth, responsible for generating collagen, elastin, and hyaluronic acid, essential for resilient skin.

How do polynucleotides differ to injectable skin boosters, like Profhilo?

Polynucleotides and injectable skin boosters have similar effects, but rather than merely hydrating, like hyaluronic acid skin boosters such as Profhilo, polynucleotides actively signal cells to produce collagen and elastin. They address areas where many skin boosters cannot, such as the eyes, lips, and forehead.

Where are polynucleotides typically injected?

Polynucleotides can be effectively used for various facial areas including under the eyes, neck, and even the jawline and cheekbones. Currently, the most sought-after application tends to be the under-eye area.

The introduction of polynucleotides for under-eye treatment is revolutionising cosmetic procedures. Many doctors state that they have a significant number of patients who are concerned about their under-eye area and wouldn't qualify for tear-trough filler due to under-eye bags or tissue elasticity issues, but thanks to polynucleotides, they can significantly improve this area.

Additionally, for individuals already receiving tear-trough filler for hollowing, incorporating polynucleotides into the treatment plan often allows for longer intervals between filler sessions.

Who are suitable candidates for polynucleotide treatments?

Polynucleotide contains animal-derived ingredients, making it unsuitable for vegetarians, vegans, or individuals with fish allergies. Additionally, it is not recommended during pregnancy or while breastfeeding, as is the case with any injectable procedures.  However, due to its natural composition and versatility in application, it will be suitable for most patients.

Furthermore, a comprehensive medical history should be provided before proceeding with any aesthetic procedures.

What do polynucleotides treatments involve?

Polynucleotides treatment typically involves two to three sessions, spaced approximately two weeks apart, depending on the patient's needs. Before administering the injections, the doctor will apply local anaesthetic cream to numb the area, and then inject the product into the targeted area of the face or neck.

For under-eye treatments, doctors tend to avoid using needles and opt for a blunt-tipped cannula inserted through a single point in the cheek. This technique helps minimise bruising and swelling in the area.

The procedure itself is relatively quick, and although there may be some discomfort during the injections, most patients tolerate it well.

When do you see the results of polynucleotides, and how long do they last?

Patients will begin to notice results quite soon after the initial session, but the second session jumpstarts the remodelling process. The product continues its effects for the first 12 weeks, progressively improving over time. However, patients will experience an early improvement and lift after the first session.

Typically, the effects of polynucleotide treatments last for approximately six months before requiring a maintenance session.

Can you combine polynucleotides with other cosmetic treatments?

Polynucleotides are versatile, and compatible with various energy-based treatments. They address concerns such as dark circles, under-eye hollowing, and crepey skin around the eyes.

Polynucleotides can be combined with treatments such as Focus Dual which is a radiofrequency skin-tightening treatment, as well as certain laser therapies and microneedling.

Although polynucleotides can be used alongside dermal fillers, some doctors underscore the importance of individualised treatment plans. Some adopt a sequential approach, preferring to address significant hollowing under the eyes with tear-trough filler initially and then introducing polynucleotides to enhance skin quality. It is crucial to evaluate the patient's needs during the consultation, to tailor their treatment plans and to ensure realistic goals and safe, effective outcomes.

What are the risks associated with injectable polynucleotides?

Like with any injectable procedure, there are risks to consider. Despite claims on social media, polynucleotide treatments aren't entirely risk-free. That being said, compared to other injectables, the risks are typically lower depending on the skill and technique of the person treating you.

It's important to understand that, unlike dermal fillers, polynucleotide treatments can't be reversed because the product isn't dissolvable. Common risks linked to injectables such as polynucleotide treatments may include bruising and swelling.

How can you choose a trusted practitioner for injectable polynucleotides?

First and foremost, you must thoroughly research your chosen medical professional. It's crucial to understand their professional qualifications, training and experience in this field. You may also wish to ask if they have any before and after photos of patients they have already treated, so that you can get an understanding of what your results might be like.

Resist the temptation to base your decision solely on cost or social media popularity. Experience and quality come at a price, and investing in a high-quality practitioner using premium products is ultimately worthwhile.

How much do polynucleotides treatments cost?

The cost per session can range between £600 to £900, depending on the size of the treated area.

If you would like to book a consultation with Dr Ariel Haus, do not hesitate to do so by visiting his Top Doctors profile today.