Anti-cyclic citrullinated peptide antibody (anti-CCP) test

What is analysed in an anti-CCP antibody test?

The anti-CCP antibody test looks for cyclic citrullinated peptide antibody (anti-CCP) in the blood.

What does the result mean?

The presence of anti-CCP antibodies in the blood can be a sign of rheumatoid arthritis. 

Why is this test carried out?

The anti-CCP antibody test is used to diagnose rheumatoid arthritis.

When should the test be done?

You may need this test if you have symptoms of rheumatoid arthritis, such as joint pain, joint stiffness, especially in the morning, joint swelling, fatigue, low-grade fever. You may also need this test if other tests did not confirm or rule out the diagnosis of rheumatoid arthritis.

What sample is required?

A healthcare professional takes a blood sample from a vein in your arm with a small needle.

Is any preparation needed before the test?

Tell your doctor or healthcare professional about all the medicines, vitamins, and supplements you take. They may ask you to stop taking some for 8 hours before the test.

How is it used?

The anti-CCP antibody test is used to diagnose rheumatoid arthritis. It is usually used together with or after a rheumatoid factor (RF) test.

What are the normal values?

The normal values for anti-CCP antibodies are less than 20 units/mL. If the test results are greater than 20 units/mL, it is considered that the values are elevated and may be a sign of rheumatoid arthritis.