Treating Peyronie’s disease

Escrito por: Mr Aza Mohammed
Publicado:
Editado por: Lisa Heffernan

Peyronie’s disease (PD) is one of the most commonly underreported diseases affecting men. It causes penile pain and curvature during erections which makes sexual intercourse difficult and uncomfortable. It has a huge impact on men, not only at the physical level but emotionally, with 48% of men who have the condition being diagnosed with some form of clinical depression.

Urologist Mr Aza Mohammed talks about the possible causes of PD and if Xiapex is a viable treatment option.

Man sitting looking at camera-Peyronie's disease

What causes PD?

PD is caused by inflammation of the tunica albuginea, which is the outer layer of the penile cylinders (corpora cavernosa). This outer layer or sheath of elastic tissue stretches during an erection. Scar tissue called plaque forms inside the penis, resulting in a bent penis when erect.

The exact cause of inflammation is unknown but researchers believe that the plaques result from excessive scarring in susceptible patients following minor trauma during intercourse. PD can also be associated with some chronic conditions such as diabetes, hypertension and lipid abnormalities.

It’s also more common in men with Dupuytren’s contracture, an inflammatory condition involving the tendons in the hand.

 

What symptoms are related to PD?

Patients usually present with pain in the penis when the penis is erect in the early stages. When the penis is soft, there is usually no problem.

As the condition progresses, patients will feel a palpable lump in the penis and penile curvature during erection. Patients are usually recommended to bring photographic evidence of the curvature to their doctor upon consultation, so the doctor can offer an accurate assessment.

 

Treating PD

The principle of treating PD is to restore the function of the penis by correcting the curvature to enable penetration. One of the non-surgical methods of treatment is intralesional injection therapy, which involves injecting a substance directly into the Peyronie’s plaque.

 

Xiapex

This involves injecting an enzyme called collagenase into the PD plaque to dissolve the collagen fibres that largely make up the plaque. This will soften the plaque and reduce the degree of curvature.

The injection has been tested scientifically and has been proven to improve the degree of curvature. The success of initial clinical trials has granted Xiapex American FDA and European EMA approval.

However, for optimal results, it’s advised that only patients with a degree of curvature that’s less than 90o be selected for the procedure. Patients must also perform stretching exercises at least 3-4 times a week for treatment to be a success. Treatment can be repeated depending on how the patient responds to the treatment initially. A maximum of three injections should be carried out.

Xiapex-treating Peyronie's disease

Is Xiapex better than surgery?

Xiapex is a better option than surgery for anyone with a degree of curvature less than 90 o, in that:

1. It’s an office-based procedure

2. Performed under local anaesthesia

3. Well tolerated with minimal side effects

4. With a short recovery time

5. Minimally invasive

Patients with severe and more complex curvatures should opt to have surgery.

 

If you think you might have Peyronie’s disease, consult a urologist like Mr Aza Mohammed.

Por Mr Aza Mohammed
Urología

El Sr. Aza Mohammed es un destacado consultor en cirugía urológica , con más de 20 años de experiencia en el campo de la urología y la salud masculina. El Sr. Mohammed está especializado en el tratamiento de cálculos renales complejos y en el tratamiento mínimamente invasivo de los síntomas de la próstata , incluidos UroLift y TURP . También tiene una vasta experiencia en el manejo de los cánceres urológicos , el manejo de la disfunción eréctil y la curvatura del pene (enfermedad de Peyronie), el manejo de la incontinencia urinaria femenina, así como el manejo de afecciones urológicas generales.

El Sr. Mohammed ha recibido una amplia capacitación tanto en el Reino Unido como en el extranjero, después de haber trabajado en los principales hospitales universitarios de East Midlands y el oeste de Escocia, antes de emprender una investigación en Uro-oncología en la Universidad de Toronto, Canadá. Está certificado por el Consejo de Urología del Reino Unido y Europa y es miembro del Royal College of Surgeons of Edinburgh. Desde 2016, el Sr. Mohammed ha sido un cirujano especialista en urología en Luton y Dunstable Hospital NHS Foundation Trust.

El Sr. Mohammed ha publicado más de 30 artículos en revistas revisadas por pares y ha presentado en reuniones y conferencias nacionales e internacionales. Ha participado en varios proyectos de investigación a lo largo de su carrera en diversas afecciones urológicas, y actualmente es el principal investigador y supervisor de investigaciones de doctorado en el tratamiento de hombres con disfunción eréctil.

Ver perfil

Valoración general de sus pacientes


  • Tratamientos relacionados
  • Sexually transmitted infections (STIs)
    Vaginoplasty
    Penis Enlargement (Phalloplasty)
    Adult circumcision
    Laparoscopy
    Urologic Oncology
    Geriatric Urology
    Kidney transplantation
    Phimosis
    Short frenulum
    Este sitio web utiliza Cookies propias y de terceros para recopilar información con la finalidad de mejorar nuestros servicios, para mostrarle publicidad relacionada con sus preferencias, así como analizar sus hábitos de navegación. El usuario tiene la posibilidad de configurar sus preferencias AQUI.