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Natural IVF

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Created: 11/09/2023
Edited: 14/09/2023
Written by: Sophie Kennedy

What does Natural IVF involve?

Natural IVF, also known as Mild IVF, is an alternative approach to traditional in vitro fertilisation (IVF) that minimises the use of ovarian stimulation medications. In this method, fertility specialists aim to retrieve and fertilise the woman's naturally occurring eggs during her regular menstrual cycle. Unlike conventional IVF, which relies on high doses of hormones to stimulate the ovaries to produce multiple eggs, Natural IVF takes a gentler approach.

Who is a suitable candidate for Natural IVF?

Women with ovarian sensitivity

Natural IVF is often considered for women who are sensitive to ovarian stimulation drugs, experiencing adverse side effects, or at risk of ovarian hyperstimulation syndrome (OHSS). It provides a safer and more comfortable option for these individuals.


Women with certain medical conditions

Some women may have medical conditions that make traditional IVF risky or challenging. Natural IVF can be a suitable choice for those with conditions such as polycystic ovary syndrome (PCOS) or a history of poor response to stimulation.


How does Natural IVF differ from traditional IVF?

Minimal ovarian stimulation

In Natural IVF, or Mild IVF, minimal or no ovarian stimulation drugs are administered. This approach allows the body to produce one or a few naturally matured eggs instead of multiple eggs.


Timing

The egg retrieval in Natural IVF is scheduled to align with the woman's natural ovulation, usually without suppressing her natural cycle. This timing is critical for the success of the procedure.


Egg retrieval

As with traditional IVF, eggs are retrieved using a minor surgical procedure. The retrieved eggs are then fertilised with sperm in the laboratory.


What are the benefits of Natural IVF?

Reduced medication use

Natural IVF minimises or eliminates the need for high-dose ovarian stimulation drugs, reducing the risk of associated side effects and complications.


Lower cost

Since fewer medications are used in Natural IVF, it may be a more cost-effective option for some patients compared to conventional IVF.


Fewer embryos

Natural IVF typically results in fewer eggs and embryos. While this may reduce the number of embryos available for transfer or freezing, it can also lead to more careful selection of high-quality embryos.


Is Natural IVF as effective as traditional IVF?

Natural IVF may yield fewer eggs and embryos compared to traditional IVF, potentially impacting the chances of success. However, its suitability depends on the individual's specific circumstances and medical history. Fertility specialists will evaluate each patient's situation to determine the most appropriate approach to maximise the chances of achieving a successful pregnancy.

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Dr Anu Chawla
Written in association with: Dr Anu ChawlaSenior Specialist in Reproductive Medicine in Central London
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