Oestradiol HRT: How do the formulations differ?

Written by: Mr Mahantesh Karoshi
Published:
Edited by: Conor Dunworth

In his latest online article, renowned women’s health expert and consultant gynaecologist Mr Mahantesh Karoshi dives into the world of hormone replacement therapy (HRT) and tells us about the different formulations of oestradiol and their effects on blood oestradiol levels.

 

What is the role of oestradiol?

Oestradiol is a hormone that is naturally produced by the ovaries in women. It plays a key role in regulating the menstrual cycle, bone health, and overall well-being. However, as women age and approach menopause, their levels of oestradiol decrease, which can lead to a range of symptoms such as hot flushes, mood swings, and vaginal dryness.

 

Is it used in hormone replacement therapy (HRT)?

HRT involves the use of hormones to replace those that are no longer produced in sufficient quantities by the body. Oestradiol is one of the most commonly used hormones in HRT, and it comes in a variety of different formulations, including pills, patches, creams, and injections.

 

How do the formulations differ?

Each formulation has its own benefits and drawbacks, and they can affect blood oestradiol levels in different ways. For example, oral oestradiol pills are absorbed by the liver, which can result in higher levels of oestradiol in the bloodstream. Transdermal patches, on the other hand, deliver a steady stream of oestradiol over a longer period of time, resulting in more stable blood levels.

 

It's important to note that the goal of HRT is not necessarily to achieve a specific blood oestradiol level, but rather to alleviate symptoms and improve overall quality of life. That being said, blood tests can be useful in a few situations to monitor hormone levels and adjust treatment as needed.

 

 

How do I know if HRT is the right choice for me?

If one is considering HRT, it's important to talk to your healthcare provider about the different options available and which one may be best for you based on your individual needs and medical history.

Remember, HRT is a personal decision and not everyone will choose to pursue it. But for those who do, it can be a valuable tool in managing symptoms and improving overall health and well-being.

 

 

If you would like to book a consultation with Mr Mahantesh Karoshi, you can do so today via his Top Doctors profile. 

By Mr Mahantesh Karoshi
Obstetrics & gynaecology

Mr Mahantesh Karoshi is a London-based women’s health expert and consultant gynaecologist, with a special interest in ovarian cysts, heavy menstrual bleeding, infertility, fibroids, and adenomyosis. He is currently one of the most highly-rated gynaecologists in London with a very good reputation amongst his patients and peers.

Mr Karoshi's work is recognised internationally, having volunteered in Ethiopia’s Gimbie Hospital, and later receiving the Bernhard Baron Travelling Fellowship from the Royal College of Obstetricians and Gynaecologists which led to his work in the University of Buenos Aires. Here he worked on the techniques needed to surgically manage morbidly adherent placental disorders - a serious condition that can occur in women with multiple caesarean sections.

He believes in an open doctor-patient relationship, being sure to include the patient and educating them so that they understand their condition better and they can be directly involved in their care and management at every stage. Aside from his clinical work, he is actively involved in research, which together with his experience, has given him the opportunity to publish the first stand-alone textbook on postpartum haemorrhage which was launched by HRH Princess Anne.

At the core of Mr Karoshi's practice is a high standard of professionalism where patients are involved in their treatment and where the latest techniques and advancements are used to provide an extremely high level of care.

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