Everything you need to know about diabetic neuropathy

Written by: Dr Prash Vas
Published:
Edited by: Aoife Maguire

What is diabetic neuropathy?

Diabetic neuropathy is any involvement of the nerves in someone with diabetes, where the cause cannot be attributed to any other reason. Essentially diabetic neuropathy often is a diagnosis of exclusion.

 

It is the most common form of neuropathy worldwide, except for in certain countries where alcohol-related neuropathy is predominant.

 

Any nerve can be affected by the impact of diabetes so it can present in many different ways.

 

 

What are the different types of diabetic neuropathy?

The diiferent types of diabetic neuropathy depend on the nerves involved. Typically diabetic neuropathy affects the extremeties- this is the most common presentation.

 

Patients get a stocking type neuropathy which starts in the tips of the toes and progresses up almost like a stocking. Additionally, the hands may also be affected. Patients can get what they typically used to call a glove and stocking involvment.

 

However, no nerve is safe from the impact of diabetes. Depending on where the nerves are involved, there can be different presentations of diabetic neuropathy.

 

What doctors call diabetic neuropathy however, is the classical stocking type neuropathy, which is the most common presentation. This neuropathy increases the risk of getting diabetic foot ulcers, increases the risk of developing pain and of course can lead to other foot problems such as charcot arthropathy.

 

You can get neuropathy in different regions of the body. It can affect the nerves that run the heart and the nerves in the gut, therefore you get different presentations, depending on the region that is predominantly involved.

 

Can you recover from diabetic neuropathy?

Diabetic neuropathy happens over a period of time, often years to decades. It does not happen overnight and recovery from such damage depends on where the patient is in the scheme of the damage.

 

There are nerves that mediate our sensory responses and there are nerves that mediate our motor and more complex sensory responses. Some of these nerves, if caught early, may recover in time but if the damage is extensive, such as if someone’s come to a light late into the illness and where there is true loss of sensation, that cannot often be reversed.

 

In summary, some of the sensory perceptions can be reversed, if picked up early but the motor components or changes that happen because of advanced nerve loss can often be very difficult to reverse or are never reversed.

 

Why is diabetic neuropathy worse at night?

Diabetic neuropathy, on its own, does not change whether it’s day or night.

 

What changes is the discomfort or the symptoms patients experience and typically this is worse at night. This is because at that time the brain does not have multiple sensory involvement.

 

Therefore it is focusing on resting and then the pain experience is heightened, whereas during the day, your brain is involved with multiple other things; you have the same symptoms but because the brain is busy processing other things, you don’t experience the pain to the same amount as at night, when the rest of the applications are on silent mode.

 

It is not that the neuropathy is worse, it is that the discomfort, the symptom component is worse at night.

 

 

By Dr Prash Vas
Endocrinology, diabetes & metabolism

Prash Vas (MBBS, FRCP, PhD) holds a dual certification in Diabetes/Endocrinology and General Internal Medicine and has extensive experience as a consultant at the highest level since 2013. In the NHS, he is currently the King’s Health Partners consultant in diabetes and endocrinology with a specialist focus in diabetes Foot Medicine being based both at King’s College Hospital and Guy’s and St Thomas’ Hospitals. Prior to that completed his training in Diabetes and Endocrinology at Addenbrookes Hospital, Cambridge. He is an honorary senior clinical lecturer at King’s College, London and a visiting professor at Staffordshire University. Additionally, he chairs the SouthEast Thames Diabetes Physicians Group (SETDPG) and is the current research lead for diabetes at King’s College Hospital.  

 

Dr Vas has extensive clinical experience in all aspects of diabetes care with a special interest in the complex management of Type 2 and Type 1 diabetes. In endocrinology, he has an interest in thyroid disorders and works alongside key experts for complex endocrine presentations which often require multi-professional consensusDr Vas is internationally recognised in the management of diabetic foot disease including neuropathic pain and has extensively championed the cause of early recognition of the ‘diabetic foot attack’. From a general medical perspective, he has wide experience in the management of a wide range of acute and chronic medical disorders and in providing care coordination required for a successful peri-operative pathway. Dr Vas has a focus on patient-centred care and is passionate about a collaborative approach towards achieving optimal outcomes in healthcare. 

 

A well-established academic, Dr Vas’s current research is focused on the lower limb complications of diabetes including the aetiopathogenesis and treatment of diabetic foot ulcers, diabetic neuropathy (especially small-fibre neuropathy) neuropathic pain and the validation of new techniques designed for the early detection of neuropathy. He also has an interest in endocrine conditions which can lead to small fibre neuropathy, in particular thyroid disorders. He ranks highly for his research output in diabetic foot (Expertscape 2022 World Top 20) and diabetic neuropathy (Expertscape 2022 World Top 50). He is frequently invited to speak internationally on these subjects. He is a board member of the Diabetic Foot Study Group (DFSG) and serves as an expert to the International Working Group on Diabetic Foot (IWGDF)and has provided expert input to the National Institute for Health and Care Excellence (NICE). He is the co-founder of the Diabetes Neuropathy Network, a global consortium of clinicians devoted to raising awareness about the perils of diabetic neuropathy. 

 

Dr Vas is available for consultation for conditions related to Diabetes/Endocrinology and General Internal Medicine at the London Bridge Hospital, HCA at the Shard, The London Clinic and the Guthrie International Wing and has admission rights at London Bridge Hospital and The London Clinic facilities. If you would wish to discuss how best your care could be coordinated on your medical visit to London, please contact Dr Vas by email: [email protected] 

 

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