What is being analysed?

Antimitochondrial antibodies (AMA) are proteins that target the mitochondria, the energy-producing structures within cells. The analysis involves detecting the presence and concentration of these antibodies in a patient's blood sample.

What does the result mean?

A positive result indicates the presence of AMA, which is associated with conditions such as primary biliary cholangitis (PBC), an autoimmune liver disease. A negative result suggests the absence of these antibodies.

Why perform the analysis?

AMA analysis is crucial for diagnosing autoimmune liver diseases, especially PBC. Early detection allows for timely intervention and management, preventing the progression of liver damage.

When to conduct the analysis?

AMA analysis is typically ordered when a patient exhibits symptoms of liver dysfunction, such as fatigue, itching, or jaundice. It is also part of routine screening for individuals at higher risk, such as those with a family history of autoimmune liver diseases.

What sample is required?

A blood sample is collected for AMA analysis. The procedure is minimally invasive and can be performed in a healthcare provider's office or a laboratory.

Is any prior preparation necessary?

No specific preparation is required before an AMA analysis. However, it is essential to inform the healthcare provider about any medications or supplements the patient may be taking.

How is it used?

AMA analysis aids in the diagnosis of PBC and other autoimmune liver diseases. Additionally, it helps assess the severity of the condition and monitor the effectiveness of treatment.

What are the normal values?

What does it mean to have altered values?

• Positive result: The presence of AMA suggests an autoimmune liver disease, such as PBC. Further tests and clinical evaluation are needed for a definitive diagnosis.
• Negative result: The absence of AMA does not rule out liver disease entirely, and additional tests may be required for a comprehensive assessment.

In conclusion, AMA analysis is a valuable tool in the diagnosis and management of autoimmune liver diseases, offering insights into the patient's condition and guiding appropriate medical interventions. Regular monitoring of AMA levels is crucial for assessing treatment effectiveness and ensuring the overall liver health of the patient.