What is acute kidney injury, and what are the causes?

Written by: Dr Rhys Evans
Published:
Edited by: Conor Lynch

In this article below, highly experienced and reputable consultant nephrologist, Mr Rhys Evans, discusses acute kidney injury, as he outlines the associated symptoms and causes, whilst also detailing the diagnosis and treatment.

 

What is acute kidney injury?

Acute kidney injury (AKI) is a sudden reduction in kidney function that occurs within a few hours or a few days. AKI can cause a build-up of waste products in your blood and makes it hard for your kidneys to keep the right balance of fluid in your body. AKI can also affect other organs such as the brain, heart, and lungs.

 

What are the main associated symptoms?

Often patients with AKI have few symptoms unless the condition is severe. Symptoms may relate to the underlying cause of AKI. Symptoms of AKI itself may include:

  • A reduction in the amount of urine being produced
  • Swelling in legs, ankles, and around the eyes
  • Fatigue or tiredness
  • Shortness of breath
  • Confusion
  • Nausea
  • Seizures or coma in severe cases

 

What are the main causes of AKI?

AKI can have many different causes. It can be caused by decreased blood flow and perfusion of the kidneys, medications, or other substances that are toxic to the kidneys, medical conditions that lead to direct damage of the kidneys, or obstruction to urinary flow. Risk factors for its development include increased age, diabetes, high blood pressure, pre-existing chronic kidney disease, and liver or heart disease.

 

How is AKI diagnosed?

Diagnosis of AKI is based on a reduction in urine output and blood tests that measure kidney function.

 

How is AKI treated?

The most important thing is to quickly identify and treat the underlying cause of AKI. Alongside this, treatments to support kidney function may be needed. These include appropriate hydration with oral or intravenous fluids, and medications that help to correct electrolyte levels in the blood. In severe cases, treatment of AKI requires hospitalization until recovery, and dialysis may be needed to remove toxins from the blood.

 

What is the best way to reduce my risk of suffering an acute kidney injury?

To reduce the risk of AKI, it is recommended to manage any existing kidney or other chronic health problems appropriately and maintain a healthy lifestyle through regular exercise and a healthy diet. Prior to taking any over-the-counter medications, always check these are safe for your kidneys and avoid taking long courses of non-steroidal anti-inflammatory drugs if possible. If you are at risk of AKI and you develop an acute illness, or if you have any symptoms of AKI, then see your doctor to get your kidney function checked.

 

If you wish to book an appointment with Mr Rhys Evans today, just visit his Top Doctors profile.  

By Dr Rhys Evans
Nephrology

Dr Rhys Evans is a highly experienced and esteemed associate professor of renal medicine and consultant nephrologist at the UCL Centre for Kidney and Bladder Health, Royal Free Hospital. He specialises in acute kidney injury, chronic kidney disease, electrolyte disorders (tubular kidney diseases), hypertension, kidney infections and kidney transplantation, and currently practises at the Cromwell Hospital and the Royal Free London Private Patients Unit.

Dr Evans studied medicine at Cambridge University and University College London Medical School, qualifying in 2007. He has sub-speciality expertise in transplantation, including donor and recipient assessment, as well as all aspects of post-transplant care. He is the deputy lead of the UCL Centre for Transplantation and is principal investigator on a number of clinical trials. He also has sub-specialty expertise in the management of patients with inherited and acquired tubular kidney diseases, including unexplained electrolyte disorders, and helps run the clinical service of the London Tubular Centre.

Dr Evans is an academic clinician with a diverse research portfolio. He was awarded a PhD from UCL for translational work investigating the impact of salt on the immune system during which he provided the first description of immunodeficiency in patients with inherited salt-losing tubulopathies. He continues to investigate changes in immunity in patients with tubular kidney disease and hypertension.

He was awarded the UCL Oliver Wrong Prize for an outstanding contribution to Renal Physiology research in 2021 and is a member of the British Transplant Society and the International Society of Nephrology but to mention a few. His other focus is aimed at improving the care of patients with kidney disease in low-resource settings, which he has done in a number of different countries worldwide.

He has previously worked as a clinical lecturer at the University of Malawi and has published widely on the epidemiology of kidney disease in Africa and novel tools to detect it. He has a friendly approach to medicine and strongly believes in shared decision making with patients and their families.

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